PanelApp (stage)
  1. Genes and Genomic Entities
  2. RET

RET

ret proto-oncogene
OMIM: 164761, Gene2Phenotype

23 panels

Panel Reviews Mode of inheritance Details
23 panels

Green RET in Vasculitis


Level 2: Immunological disorders
Version 0.82

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green RET in Congenital anomalies of the kidney and urinary tract (CAKUT) Nonsyndromic


Level 2: Renal and urinary tract disorders
Version 0.117

Component of the following Super Panels:

  • Congenital abnormalities of the kidneys and urinary tract (CAKUT)_SuperPanel
  • Kidneyome_SuperPanel

    		•  review Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Red RET in Cataract


    Level 2: Ophthalmological disorders
    Version 0.366

    		review Unknown
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services

    Red RET in Central Hypoventilation


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.5

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services
    Phenotypes
    • Central hypoventilation syndrome, congenital, MIM#209880

    Green RET in Hirschsprung disease


    Level 2: Gastroenterological disorders
    Version 0.25

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Multiple endocrine neoplasia IIA, MIM# 171400
    • Hirschsprung disease

    Green RET in Hypercalcaemia


    Level 2: Endocrine disorders
    Version 1.2

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Multiple endocrine neoplasia IIA, MIM# 171400
    • Multiple endocrine neoplasia IIB, MIM# 162300

    Green RET in Incidentalome


    Version 0.301

    		review Unknown
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Red RET in Interstitial Lung Disease


    Level 2: Respiratory disorders
    Version 1.0

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Victorian Clinical Genetics Services
    Phenotypes
    • Central hypoventilation syndrome, congenital, MIM#209880

    Green RET in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 0.131

    		review Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Green RET in Calcium and Phosphate disorders


    Level 2: Renal and urinary tract disorders; Endocrine disorders
    Version 1.24

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Multiple endocrine neoplasia IIA, MIM# 171400
    • Multiple endocrine neoplasia IIB, MIM# 162300

    Green RET in Additional findings_Adult


    Level 2: Screening
    Version 0.166

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Multiple endocrine neoplasia IIA, MIM# 171400
    • Multiple endocrine neoplasia IIB, MIM# 162300

    Red RET in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.6063

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • Genetic Health Queensland
    Phenotypes
    • Central hypoventilation syndrome, congenital, MIM#209880
    • Medullary thyroid carcinoma, MIM#155240
    • Multiple endocrine neoplasia IIA, MIM#171400
    • Multiple endocrine neoplasia IIB, MIM#162300

    Red RET in CGC_86


    Version 0.2

    		review Other
    Sources
    • CGC_86
    Phenotypes
    • Multiple endocrine neoplasia, type 2b
    • Multiple endocrine neoplasia, type 2a
    • Familial medullary thyroid carcinoma

    Red RET in NCGC


    Version 0.2

    		review Other
    Sources
    • NCGC
    Phenotypes
    • Multiple endocrine neoplasia, type 2b
    • Multiple endocrine neoplasia, type 2a
    • Familial medullary thyroid carcinoma

    Red RET in TCGA_PANCAN_2018


    Version 0.2

    		review Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • Familial medullary thyroid carcinoma
    • Multiple endocrine neoplasia, type 2b
    • Multiple endocrine neoplasia, type 2a

    Green RET in Gastrointestinal neuromuscular disease


    Level 2: Gastroenterological disorders
    Version 1.24

    Component of the following Super Panels:

  • Neuromuscular Superpanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Royal Melbourne Hospital
    Phenotypes
    • Central hypoventilation syndrome, congenital, MIM# 209880
    • Multiple endocrine neoplasia IIA, MIM# 171400
    • Multiple endocrine neoplasia IIB, MIM# 162300

    Green RET in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category A gene
    • Expert Review Green
    Phenotypes
    • Multiple endocrine neoplasia IIA
    • Multiple endocrine neoplasia IIB

    Green RET in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		review Unknown
    Sources
    • NSW Health Pathology
    • Expert Review Green

    Green RET in Fetal anomalies


    Version 1.255

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Genetic Health Queensland
    Phenotypes
    • Central hypoventilation syndrome, congenital, MIM#209880
    • Multiple endocrine neoplasia IIA, MIM#171400
    • Multiple endocrine neoplasia IIB, MIM#162300

    Green RET in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.113

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • BabySeq Category A gene
    Phenotypes
    • Multiple endocrine neoplasia IIB
    • Multiple endocrine neoplasia IIA
    Tags
    • cancer
    • treatable

    Green RET in Renal Tubulopathies and related disorders


    Level 2: Renal and urinary tract disorders
    Version 1.14

    Component of the following Super Panels:

  • Kidneyome_SuperPanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    • Expert Review Green
    • Expert list
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Multiple endocrine neoplasia IIB, MIM# 162300
    • Multiple endocrine neoplasia IIA, MIM# 171400

    Green RET in Facial papules


    Level 2: Dermatological disorders
    Version 1.0

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • multiple endocrine neoplasia type 2B MONDO:0008082

    Green RET in Transplant Co-Morbidity Superpanel


    Level 2: Screening
    Version 0.18

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Melbourne Genomics Health Alliance
    Phenotypes
    • Multiple endocrine neoplasia IIB, MIM# 162300
    • Multiple endocrine neoplasia IIA, MIM# 171400