PanelApp (stage)
  1. Genes and Genomic Entities
  2. MET

MET

MET proto-oncogene, receptor tyrosine kinase
OMIM: 164860, Gene2Phenotype

11 panels

Panel Reviews Mode of inheritance Details
11 panels

Amber MET in Arthrogryposis


Level 2: Neurology and neurodevelopmental disorders
Version 0.411

Component of the following Super Panels:

  • Neuromuscular Superpanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • ?Arthrogryposis, distal, type 11 (MIM#620019), AD

    Red MET in Autism


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.198

    		review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Expert list
    • Victorian Clinical Genetics Services
    Phenotypes
    • ?Deafness, autosomal recessive 97, OMIM #616705
    • {Osteofibrous dysplasia, susceptibility to}, OMIM #607278

    Green MET in Mendeliome


    Version 1.1891

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Arthrogryposis, distal, type 11 (MIM#620019), AD
    • Renal cell carcinoma, papillary, 1, familial and somatic, MIM# 605074
    • Papillary renal cell carcinoma MONDO:0017884

    Red MET in Deafness_IsolatedAndComplex


    Level 2: Hearing and ear disorders
    Version 1.194

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • Deafness, autosomal recessive 97, MIM# 616705

    Red MET in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.6063

    		review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • ?Deafness, autosomal recessive 97, OMIM #616705
    • {Osteofibrous dysplasia, susceptibility to}, OMIM #607278

    Red MET in NCGC


    Version 0.2

    		review Other
    Sources
    • NCGC
    Phenotypes
    • Renal cell carcinoma, papillary, 1

    Red MET in TCGA_PANCAN_2018


    Version 0.2

    		review Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • Renal cell carcinoma, papillary, 1

    Red MET in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 0.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review BOTH monoallelic and biallelic, autosomal or pseudoautosomal
    Sources
    • Expert list

    Amber MET in Vascular Malformations_Somatic


    Level 2: Cardiovascular disorders
    Version 1.13

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review Other
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • lymphovenous malformation
    • overgrowth

    Green MET in Renal cancer


    Level 2: Cancer susceptibility
    Version 0.4

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • SA Pathology
    Phenotypes
    • Hereditary papillary renal carcinoma with type 1 papillary tumors

    Green MET in Incidentalome_PREGEN_DRAFT


    Version 0.43

    		review Unknown
    Sources
    • NSW Health Pathology
    • Expert Review Green