PanelApp (stage)
  1. Genes and Genomic Entities
  2. HRAS

HRAS

HRas proto-oncogene, GTPase
OMIM: 190020, Gene2Phenotype

24 panels

Panel Reviews Mode of inheritance Details
24 panels

Green HRAS in Congenital Heart Defect


Level 2: Cardiovascular disorders
Version 0.418

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green HRAS in Hydrops fetalis


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.313

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green HRAS in Interstitial Lung Disease


Level 2: Respiratory disorders
Version 1.0

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Costello syndrome 218040
  • chILD, pulmonary arterial hypertension

Green HRAS in Macrocephaly_Megalencephaly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.140

review Unknown
Sources
  • Victorian Clinical Genetics Services
  • Expert Review Green

Green HRAS in Mendeliome


Version 1.1891

review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Costello syndrome, MIM# 218040

Amber HRAS in Muscular dystrophy and myopathy_Paediatric


Level 2: Neurology and neurodevelopmental disorders
Version 1.33

Component of the following Super Panels:

  • Myopathy Superpanel
  • Neuromuscular Superpanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Other
    • Expert Review Amber
    Phenotypes
    • Congenital myopathy with excess of muscle spindles (MIM#218040)

    Green HRAS in Cancer Predisposition_Paediatric


    Level 2: Cancer
    Version 0.131

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Costello syndrome, MIM# 218040

    Green HRAS in Rasopathy


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 0.105

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    Phenotypes
    • Costello syndrome, MIM# 218040

    Green HRAS in Calcium and Phosphate disorders


    Level 2: Renal and urinary tract disorders; Endocrine disorders
    Version 1.24

    		review Other
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Costello syndrome MONDO:0009026

    Green HRAS in Genetic Epilepsy


    Level 2: Neurology and neurodevelopmental disorders
    Version 1.33

    Component of the following Super Panels:

  • Progressive Neurological Conditions

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Australian Genomics Health Alliance Epilepsy Flagship
    • Victorian Clinical Genetics Services
    Phenotypes
    • Costello syndrome, MIM# 218040

    Green HRAS in Callosome


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.522

    		review Unknown
    Sources
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Green HRAS in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.6063

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genetic Health Queensland
    Phenotypes
    • Costello syndrome, MIM# 218040

    Red HRAS in Vascular Malformations_Germline


    Level 2: Cardiovascular disorders
    Version 1.11

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review Other
    Sources
    • Expert Review Red
    • Expert list
    Phenotypes
    • Extracranial arteriovenous malformations
    • Vascular malformation/overgrowth syndromes
    Tags
    • somatic

    Red HRAS in CGC_86


    Version 0.2

    		review Other
    Sources
    • CGC_86
    Phenotypes
    • Costello syndrome

    Red HRAS in NCGC


    Version 0.2

    		review Other
    Sources
    • NCGC
    Phenotypes
    • Costello syndrome

    Red HRAS in TCGA_PANCAN_2018


    Version 0.2

    		review Other
    Sources
    • TCGA_PANCAN_2018
    Phenotypes
    • Costello syndrome

    Green HRAS in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 0.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert Review
    Phenotypes
    • Costello syndrome 218040

    Green HRAS in Vascular Malformations_Somatic


    Level 2: Cardiovascular disorders
    Version 1.13

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review Other
    Sources
    • Expert Review Green
    • Expert list
    • Expert list
    Phenotypes
    • Vascular malformation/overgrowth syndromes
    • Extracranial arteriovenous malformations
    Tags
    • somatic

    Green HRAS in Cardiomyopathy_Paediatric


    Level 2: Cardiovascular disorders
    Version 0.192

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • South West GLH
    • NHS GMS
    • Expert Review Green
    • Expert List
    • London South GLH
    Phenotypes
    • Costello syndrome
    • syndromic HCM

    Green HRAS in Additional findings_Paediatric


    Level 2: Screening
    Version 0.278

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • BabySeq Category A gene
    • Expert Review Green
    Phenotypes
    • Costello syndrome

    Green HRAS in Mosaic skin disorders


    Level 2: Dermatological disorders
    Version 1.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • NHS GMS
    Phenotypes
    • Phakomatosis pigmentokeratotica
    • Epidermal naevi
    • Woolly hair
    • Costello syndrome
    • Schimmelpenning syndrome
    Tags
    • somatic

    Green HRAS in Growth failure


    Version 1.76

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Victorian Clinical Genetics Services
    Phenotypes
    • Costello syndrome, MIM# 218040

    Green HRAS in Fetal anomalies


    Version 1.255

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Genetic Health Queensland
    Phenotypes
    • Costello syndrome, MIM# 218040

    Red HRAS in BabyScreen+ newborn screening


    Level 2: Screening
    Version 1.113

    		review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Red
    • BabySeq Category A gene
    Phenotypes
    • Costello syndrome, MIM# 218040