PanelApp (stage)
  1. Genes and Genomic Entities
  2. ALX3

ALX3

ALX homeobox 3
OMIM: 606014, Gene2Phenotype

10 panels

Panel Reviews Mode of inheritance Details
10 panels

Green ALX3 in Frontonasal dysplasia


Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.1

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Victorian Clinical Genetics Services
Phenotypes
  • Frontonasal dysplasia 1, MIM# 136760

Green ALX3 in Mendeliome


Version 1.1891

review BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
  • Victorian Clinical Genetics Services
Phenotypes
  • Frontonasal dysplasia 1, MIM#136760

Red ALX3 in Polydactyly


Level 2: Dysmorphic and congenital abnormality syndromes
Version 0.276

Component of the following Super Panels:

  • Limb and Digital Malformations SuperPanel

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • Genetic Health Queensland
    • Victorian Clinical Genetics Services
    Phenotypes
    • Frontonasal dysplasia 1, MIM#136760

    Amber ALX3 in Pierre Robin Sequence


    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 0.47

    		review Unknown
    Sources
    • Expert Review Amber
    • Victorian Clinical Genetics Services

    Green ALX3 in Callosome


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.522

    		review Unknown
    Sources
    • Genetic Health Queensland
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Expert Review Green

    Amber ALX3 in Intellectual disability syndromic and non-syndromic


    Level 2: Neurology and neurodevelopmental disorders
    Version 0.6063

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    • Genetic Health Queensland
    Phenotypes
    • Frontonasal dysplasia 1, MIM#136760

    Green ALX3 in Skeletal dysplasia

    Level 3: Skeletal dysplasias
    Level 2: Skeletal disorders
    Version 0.285

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Green
    • UKGTN
    • Radboud University Medical Center, Nijmegen
    • NHS GMS
    • Expert list
    • Expert list
    • Victorian Clinical Genetics Services
    Phenotypes
    • Frontonasal dysplasia 1 136760
    • Frontonasal dysplasia 1 136760 (frontorhiny)

    Red ALX3 in Lymphoedema_syndromic

    Level 3: Lymphatic Disorders
    Level 2: Cardiovascular disorders
    Version 0.12

    Component of the following Super Panels:

  • Vascular Malformations SuperPanel

    		•  review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • UKGTN
    • Radboud University Medical Center, Nijmegen
    • Expert Review Red
    Phenotypes
    • Frontonasal dysplasia 1 136760

    Amber ALX3 in Clefting disorders

    Level 3: Dysmorphic disorders
    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 0.252

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Amber
    Phenotypes
    • Frontonasal dysplasia 1, MIM# 136760
    • Frontorhiny

    Green ALX3 in Fetal anomalies


    Version 1.255

    		review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Genomics England PanelApp
    • Genetic Health Queensland
    Phenotypes
    • Frontonasal dysplasia 1, MIM#136760