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Mendeliome v0.10114 TRIM27 Zornitza Stark Marked gene: TRIM27 as ready
Mendeliome v0.10114 TRIM27 Zornitza Stark Gene: trim27 has been classified as Red List (Low Evidence).
Mendeliome v0.10114 TRIM27 Zornitza Stark Phenotypes for gene: TRIM27 were changed from to parkinson's disease
Mendeliome v0.10113 TRIM27 Zornitza Stark Classified gene: TRIM27 as Red List (low evidence)
Mendeliome v0.10113 TRIM27 Zornitza Stark Gene: trim27 has been classified as Red List (Low Evidence).
Mendeliome v0.10085 TRIM27 Ain Roesley reviewed gene: TRIM27: Rating: RED; Mode of pathogenicity: None; Publications: 34419804; Phenotypes: parkinson's disease; Mode of inheritance: None; Current diagnostic: yes
Mendeliome v0.7590 TRIM2 Zornitza Stark Marked gene: TRIM2 as ready
Mendeliome v0.7590 TRIM2 Zornitza Stark Gene: trim2 has been classified as Green List (High Evidence).
Mendeliome v0.7590 TRIM2 Zornitza Stark Phenotypes for gene: TRIM2 were changed from to Charcot-Marie-Tooth disease, type 2R, MIM# 615490; MONDO:0014208
Mendeliome v0.7589 TRIM2 Zornitza Stark Publications for gene: TRIM2 were set to
Mendeliome v0.7588 TRIM2 Zornitza Stark Mode of inheritance for gene: TRIM2 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.7587 TRIM2 Zornitza Stark reviewed gene: TRIM2: Rating: GREEN; Mode of pathogenicity: None; Publications: 23562820, 25893792, 18687884, 32815244, 32205255, 25893792; Phenotypes: Charcot-Marie-Tooth disease, type 2R, MIM# 615490, MONDO:0014208; Mode of inheritance: BIALLELIC, autosomal or pseudoautosomal
Mendeliome v0.1998 TRIM22 Zornitza Stark Marked gene: TRIM22 as ready
Mendeliome v0.1998 TRIM22 Zornitza Stark Gene: trim22 has been classified as Green List (High Evidence).
Mendeliome v0.1998 TRIM22 Zornitza Stark Classified gene: TRIM22 as Green List (high evidence)
Mendeliome v0.1998 TRIM22 Zornitza Stark Gene: trim22 has been classified as Green List (High Evidence).
Mendeliome v0.1997 TRIM22 Zornitza Stark gene: TRIM22 was added
gene: TRIM22 was added to Mendeliome. Sources: Expert list
Mode of inheritance for gene: TRIM22 was set to BIALLELIC, autosomal or pseudoautosomal
Publications for gene: TRIM22 were set to 26836588
Phenotypes for gene: TRIM22 were set to Inflammatory bowel disease
Review for gene: TRIM22 was set to GREEN
Added comment: Three unrelated families reported with bi-allelic variants in this gene, and very early onset IBD, some functional data.
Sources: Expert list
Mendeliome v0.850 Sebastian Lunke removed gene:TRIM28 from the panel
Mendeliome v0.685 TRIM28 Zornitza Stark Marked gene: TRIM28 as ready
Mendeliome v0.685 TRIM28 Zornitza Stark Gene: trim28 has been classified as Green List (High Evidence).
Mendeliome v0.685 TRIM28 Zornitza Stark Classified gene: TRIM28 as Green List (high evidence)
Mendeliome v0.685 TRIM28 Zornitza Stark Gene: trim28 has been classified as Green List (High Evidence).
Mendeliome v0.684 TRIM28 Zornitza Stark gene: TRIM28 was added
gene: TRIM28 was added to Mendeliome_VCGS. Sources: Literature
Mode of inheritance for gene: TRIM28 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for gene: TRIM28 were set to 30694527
Phenotypes for gene: TRIM28 were set to Wilm's tumour
Review for gene: TRIM28 was set to GREEN
Added comment: Eleven individuals with germline variants identified; plus one somatic. Exome sequencing on eight tumor DNA samples from six individuals showed loss-of-heterozygosity (LOH) of the TRIM28-locus by mitotic recombination in seven tumors, suggesting that TRIM28 functions as a tumor suppressor gene in Wilms tumor development.
Sources: Literature
Mendeliome v0.407 TRIM24 Zornitza Stark Marked gene: TRIM24 as ready
Mendeliome v0.407 TRIM24 Zornitza Stark Gene: trim24 has been classified as Red List (Low Evidence).
Mendeliome v0.407 TRIM24 Zornitza Stark Classified gene: TRIM24 as Red List (low evidence)
Mendeliome v0.407 TRIM24 Zornitza Stark Gene: trim24 has been classified as Red List (Low Evidence).
Mendeliome v0.406 TRIM24 Belinda Chong reviewed gene: TRIM24: Rating: RED; Mode of pathogenicity: None; Publications: ; Phenotypes: ; Mode of inheritance: None
Mendeliome v0.0 TRIM27 Zornitza Stark gene: TRIM27 was added
gene: TRIM27 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: TRIM27 was set to Unknown
Mendeliome v0.0 TRIM24 Zornitza Stark gene: TRIM24 was added
gene: TRIM24 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: TRIM24 was set to Unknown
Mendeliome v0.0 TRIM2 Zornitza Stark gene: TRIM2 was added
gene: TRIM2 was added to Mendeliome_VCGS. Sources: Expert Review Green,Victorian Clinical Genetics Services
Mode of inheritance for gene: TRIM2 was set to Unknown