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| Pharmacogenomics_Paediatric v0.48 | CYP2D6 | Zornitza Stark Publications for gene: CYP2D6 were set to 18406467 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.38 | CYP2D6 | Zornitza Stark Marked gene: CYP2D6 as ready | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.38 | CYP2D6 | Zornitza Stark Gene: cyp2d6 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.38 | CYP2D6 | Zornitza Stark Phenotypes for gene: CYP2D6 were changed from to Codeine, tramadol, oxycodone | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.37 | CYP2D6 | Zornitza Stark Classified gene: CYP2D6 as Green List (high evidence) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.37 | CYP2D6 | Zornitza Stark Gene: cyp2d6 has been classified as Green List (High Evidence). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.36 | CYP2D6 | Zornitza Stark reviewed gene: CYP2D6: Rating: GREEN; Mode of pathogenicity: None; Publications: 18406467, 24458010; Phenotypes: Codeine, tramadol, oxycodone; Mode of inheritance: None | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pharmacogenomics_Paediatric v0.33 | CYP2D6 |
David Metz changed review comment from: (24458010) Strong evidence. Risk of toxicity from codeine, tramadol, (oxycodone) if ultrarapid metaboliser. Insensitivity to codeine, tramadol, (oxycodone) if poor metaboliser. Genotype-phenotype concordance from 2 weeks of age (18406467) ; to: PMID: 18406467 Genotype-phenotype concordance from 2 weeks of age PMID: 24458010 Strong evidence. Risk of toxicity from codeine, tramadol, (oxycodone) if ultrarapid metaboliser. Insensitivity to codeine, tramadol, (oxycodone) if poor metaboliser. |
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| Pharmacogenomics_Paediatric v0.33 | CYP2D6 |
David Metz changed review comment from: (24458010) Strong evidence. Risk of toxicity from codeine (lesser extent tramadol, oxycodone) if ultrarapid metaboliser. Insensitivity to codeine (tramadol, oxycodone) if poor metaboliser. Genotype-phenotype concordance from 2 weeks of age (18406467) ; to: (24458010) Strong evidence. Risk of toxicity from codeine, tramadol, (oxycodone) if ultrarapid metaboliser. Insensitivity to codeine, tramadol, (oxycodone) if poor metaboliser. Genotype-phenotype concordance from 2 weeks of age (18406467) |
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| Pharmacogenomics_Paediatric v0.33 | CYP2D6 |
David Metz changed review comment from: Genotype-phenotype concordance from 2 weeks of age (18406467) Sources: Other; to: (24458010) Strong evidence. Risk of toxicity from codeine (lesser extent tramadol, oxycodone) if ultrarapid metaboliser. Insensitivity to codeine (tramadol, oxycodone) if poor metaboliser. Genotype-phenotype concordance from 2 weeks of age (18406467) |
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| Pharmacogenomics_Paediatric v0.33 | CYP2D6 |
David Metz gene: CYP2D6 was added gene: CYP2D6 was added to Pharmacogenomics_Paediatric. Sources: Other Mode of inheritance for gene: CYP2D6 was set to Other Publications for gene: CYP2D6 were set to 18406467 Added comment: Genotype-phenotype concordance from 2 weeks of age (18406467) Sources: Other |
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